- Original Article
- The age and dose-related hyponatremia during carbamazepine and
oxcarbazepine therapy in epileptic children
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Kyu Ha Lee, Jun Hyuk Song, Sung Ho Cha, Sa Jun Chung
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Clin Exp Pediatr. 2008;51(4):409-414. Published online April 15, 2008
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Purpose : To assess the prevalence of hyponatremia in epileptic children receiving carbamazepine or oxcarbazpine, we investigate serum sodium changes according to age, serum carbamazepine level, and daily oxcarbazepine dosage, and the prevalence of symptoms of hyponatremia.
Methods : We reviewed the clinical data of the 197 children receiving carbamazepine and/or oxcarbazepine with or without antiepileptic therapy. And these were classified... |
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- Case Report
- Surgical removal of a left ventricular thrombus caused by acute myocarditis
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Kyu Ha Lee, Min Jung Yoon, Mi Young Han, Sa Jun Chung, Soo Cheol Kim
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Clin Exp Pediatr. 2007;50(6):588-591. Published online June 15, 2007
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Left ventricular thrombus is mainly caused by anterior myocardial infarction or severe cardiac wall dysfunction of the apex, and is rarely caused by a complication of acute myocarditis. A 12-year-old female who developed symptoms of motor dysphasia and incomplete hemiparesis of the right side was admitted to the hospital. The brain MRI taken on the day of her admission showed... |
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- Clinical Lecture
- Developmental Test in Children
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Sa Jun Chung, In Kyung Sung, Hee Ju Kim, Young Joung Woo, Mun Hyang Lee, Son Moon Shin
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Clin Exp Pediatr. 2002;45(7):817-821. Published online July 15, 2002
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- Original Article
- Assessment of the Relationship between Vigabatrin and
Visual Field Defect in Children
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Sa Jun Chung, Yong Hwan Chung, Eu Hyun Cho
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Clin Exp Pediatr. 2002;45(12):1546-1550. Published online December 15, 2002
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Purpose : The authors carried out this study to determine the relationship between vigabatrin (VGB) and visual field defect..
Methods : Seventy eight patients older than 8 years who had epilepsy which had developed and been diagnosed, and were receiving add-on therapy, were the subjects of this study. If suspicious results were obtained from the initial test with the Humphrey automatic... |
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- Clinical Study of Effectiveness Topiramate in Children with Intractable Epilepsy
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Young Mi Choi, Sa Jun Chung
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Clin Exp Pediatr. 2001;44(1):62-67. Published online January 15, 2001
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Purpose : Topiramate(TPM) is a new anticonvulsant with multiple action mechanisms which should theoretically represent a wide therapeutic spectrum. However, there is still little clinical experience of its use in Asian children with epilepsy.
Methods : The patients were total 96 children who were treated with more than 2 anticonvulsants but poorly controlled seizure activity. TPM was given as add-on therapy... |
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- Analysis of Risk Factors of Readmission to Hospital for Pediatric Asthma
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Kyung Lim Yoon, Young Ho Rah, Chong-Woo Bae, Sa Jun Chung
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Clin Exp Pediatr. 2000;43(4):556-560. Published online April 15, 2000
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Purpose : The admission rates for pediatric asthma are increasing annually and are partially responsible for the increased rates of readmission. Selections of children with a high-risk of readmission and aggressive treatments of them may improve treatment outcome and cost- effectiveness. The purpose of this study is to evaluate the risk factors affecting readmission in cases of bronchial asthma in... |
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- Role of Polymorphism in HLA DQ-α and -β Chain Loci in the Pathophysiology of Autoimmune Thyroid Disease in Children with and without Turner Syndrome
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Kye Shik Shim, Kyu Chul Choeh, Sei Won Yang, Sa Jun Chung, Jin Sung Lee, Kyung Tae Lee, Sung Ho Goh, Yong Sung Kim
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Clin Exp Pediatr. 1999;42(7):980-990. Published online July 15, 1999
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Purpose : About 10% of girls with Turner syndrome may have autoimmune thyroid disease(AIT), but the disease's pathophysiology has not yet been elucidated. Accordingly, this study was performed to observe whether the pathogenesis of AIT in children with Turner syndrome and without Turner syndrome correlate with special loci of DQ α and β chain in HLA.
Methods : Blood samples were... |
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- A Clinical Study on Infantile Spasms with Vigabatrin Therapy
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Seung Jung Oh, Sung Gun Park, Hyun Ho Kang, Sa Jun Chung
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Clin Exp Pediatr. 1999;42(2):233-238. Published online February 15, 1999
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Purpose : Infantile spasms are considered an age-specific and malignant epilepsy. It is not controlled easily by general anticonvulsants. Therefore, this study aimed to assess vigabatrin(VGT) efficacy in infantile spasms.
Methods : From January 1992 to December 1995, 35 children with infantile spasms, who were diagnosed at Kyung Hee University Hospital and treated vigabatrin, were analyzed retrospectively.
Results : The ratio of... |
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- A Clinical Study on Lennox-Gastaut Syndrome
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Yong Hun Choi, Gyo Dang Koo, Yeong Ho Rah, Sa Jun Chung
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Clin Exp Pediatr. 1998;41(5):663-668. Published online May 15, 1998
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Purpose : Lennox-Gastaut syndrome is an intractable epilepsy which is comprised of several types of etiology and generalized seizures. It also combines with mental retardation. The present study was made to ascertain the clinical study on Lennox-Gastaut syndrome in Korea.
Methods : From January, 1985 to December, 1995, 31 children, diagnosed with Lennox-Gastaut syndrome at Kyung Hee University Hospital, were analyzed... |
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- The Treatment of Croup with Nebulized Budesonide and Intramuscular Dexamethasone
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Jung Woo Lee, Young Ho Rah, Chong-Woo Bae, Sa Jun Chung, Yong Mook Choi
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Clin Exp Pediatr. 1998;41(3):331-337. Published online March 15, 1998
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Purpose : Steroids have anti-inflammatory effects which reduces inflammation and edema of the tissue. Thus, corticosteroids have been used for treatment of croup. The aim this study is to compare and assess the effects of intramuscularly injected dexamethasone and nebulized budesonide in treatment of moderate or severe croup.
Methods : Between July 1995 to June 1996, we have assessed 44 inpatients... |
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- Original Article
- A Clinical Study on Infantile Spasms with Prednisolone Therapy
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Hye Sun Yoon, Young Hoon Choi, Ho Suk Lee, Yong Mook Choi, Sa Jun Chung
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Clin Exp Pediatr. 1996;39(4):522-529. Published online April 15, 1996
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Purpose : Infantile spasms are considered malignant epilepsy of infancy. Primary objectives of treatment are complete control of seizure attack and prevention of further brain damage. The aim of this study is to assess prednisolone(PDL) efficacy in infantile spasms.
Methods : From June 1985 to July 1994, 20 children with infantile spasms who were
diagnosed at Kyung Hee University Hospital and were... |
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- Original Article
- Changes in Somatostatin Immunoreactive Neurons in Rat Corebral Cortes after Systemic Kainic acid Administration
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Myung Yeun Lee, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1993;36(9):1279-1290. Published online September 15, 1993
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This study was aimed to clarify the effects of systemic kainic acid(KA) administration(10mg/kg i.p.) on somatostatin containing neurons, and to examine the distribution of somatostain immunoreactive neurons in the cerebral cortex of the rats.
Animals were sacrificed at three time points at the two, six, and ten days after the injection of KA.
Thirty-six rats were observed by using the free-floating immunohistochemical... |
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- A Clinical Study on Patients with Porencephaly
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Sung Yoon Cho, Jai Yoon Kim, Kwang Sun Han, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1993;36(7):975-981. Published online July 15, 1993
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Porencephaly is relatively rare condition defined by a defect or cavity in the cerebrum owing to a developmental malformation or to a destructive lesion.
Forty-five porencephaly patients diagnosed by Brain CT were clinically analyzed and the following results were obtained.
1) By the age group presenting initial symptoms, the peak incidence was from 1 month to below 3 years old.
2) In initial... |
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- Case Report
- A Case of Congenital Goiter with Congenital Hypothyroidism due to Organification Defect
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Ik Hee Lee, Sung Yong Jung, Thi Hyung Park, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1993;36(7):1002-1008. Published online July 15, 1993
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We experienced a case of congenital goiter with congenital hypothyroidism in 45 dayold male, who complained of respiratory difficulty and anterior neck mass.
After admission, he was diagnosed congenital hypothyroidism by the clinical manifestations and laboratory tests including biochemistry, radioimmunoassay, radioisotope study, perchlorate discharge test, and bone radiography. We obtained positive finding at the perchlorate discharge test and found that his... |
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- Original Article
- Surfactant replacement therapy in neonatal respiratory distress syndrome.
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Chan Ok Park, Boung Yul Lim, Byeong Gie Yeo, Ji Ho Song, Eun Kyung Sohn, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1991;34(9):1211-1222. Published online September 30, 1991
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Respiratory distress syndrome (RDS) in tiny infants remains a major medical challenge as they are
less tolerant of supportive care.
In 1959, after identification of the pulmonary surfactant (S), S replacement therapy were used to
treat RDS. This idea was first successfully tested on RDS infants by Fujiwara, et. al” in 1980. Now
the trial and use of S for the treatment in RDS... |
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- Experimental study on the effect of phenobarbital on Na+, K+-activated adenosine triphosphatase in microsome fractions of mouse brain.
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Seo Kyu Kim, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1991;34(7):959-970. Published online July 31, 1991
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Na+, K+-activated adenosine triphosphatase (Na+, K+-ATPase) is known to play a role as a trigger
in neurotransmitter release and may also affect the transport of calcium ion (Ca++). By doing so, Na+,
K+-ATPase, as an anticonvulsant, can modify the excitability level of cells in epilepsy. In order to
elucidate the possible mechanisms of neuropharmacological interaction between Na+, K+.ATPase
and phenobarbital, serial experimental studies were... |
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- A study for mass screening of galactosemia using galactitol level by spot urine method among Korean infants.
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Jin Tae Kim, Chong Won Bae, Sa Jun Chung, Chang Il Ahn, Suyama I , Isshiki G
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Clin Exp Pediatr. 1991;34(7):949-958. Published online July 31, 1991
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For mass screening of the galactosemia, we used spot urine method using filter paper which was
newly developed by Department of Pediatrics, Kyung Hee University Hospital and Department of
Pediatrics, Osaka City University in Japan.
We used control groups as followed, 7 of normal adults,- one patient of I, II, III types of
galactosemia, respectively. The experimental groups were 62 infants of 0 to... |
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- Changes in Auditory Brainstem Reponses (ABR) in Severe Hyperbilirubinemic Neonates with Transient Bilirubin Encephalopathy.
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Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1990;33(9):1216-1222. Published online September 30, 1990
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Many authors have reported alterations in the ABR in severe hyperbilirubinemia and ABR is an
effective non-invasive method of assessing the functional status of the auditory nerve and brainstem
sensory pathway in the management of neonatal hyperbilirubinemia.
Perlman et al reported that jaundice in the early neonatal period is associated with significant
transient aberration of ABR, suggestive of a transient bilirubin encephalopathy (TBE). And... |
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- A Case of Lissencephaly with West Syndrome.
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Byoung Yul Lim, Ji Ho Song, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1990;33(10):1413-1417. Published online October 31, 1990
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Neuronal migrational disorders of the brain represent abnormalities in the formation of the
neocortex caused by faulty migration of the subependimal neuroblasts. Lissencephaly is a rare
congenital anomaly representing an arrest of brain development before the third or fourth month of
gestaional age.
The most common clinical findings were seizure, delayed development, failure to thrive and
hydrocephalus. The authors experienced a case of lissencephaly with... |
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- A Case of Early Infantile Epileptic Encephalopathy with Suppression-burst.
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Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1989;32(9):1320-1323. Published online September 30, 1989
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The authors experienced a case of 45-day-old female newborn infant who showed the intractable
tonic spasms with series formation and hypotonia. We diagnosed it through the evaluation of the
clinical, radiological features including brain CT and electroencephalogram. The suppresion-burst
pattern in EEG and clinical features aid to the confirmation of the diagnosis.
A brief review of the related literature were made. |
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- Two Case of Transient Bilirubin Encephalopathy in Newborn.
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Eun Kyoung Sohn, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1989;32(9):1295-1299. Published online September 30, 1989
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More recently, several studies have been repotted about the abnormalities of auditory brainstem
response (ABR) in hyperbilirubinemia of newborn. By using of ABR, visual evoked potenital and
nuclear magnetic resonance techniques, some investigators suggested that transient alteration in ABR
in severely jaundiced neonates indicated reversible transient subclinical or clinical bilirubin induced
neurotoxicity. They thought it would be the early stage of kernicterus.
We experienced two... |
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- Analysis of Asymptomatic Proteinuria in School Children.
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Chong Guk Lee, Tae Sub Shim, Dong Hwan Lee, Yong Soo Yun, Chang Jun Ko, Sa Jun Chung, Hyun Soon Lee, Sung Jae Suh, Pyung Nam Kim
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Clin Exp Pediatr. 1989;32(9):1187-1194. Published online September 30, 1989
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Uriary mass screening program for the detection of proteinuria had been performed for a school-
age population in the city of Seoul since 1981. Annually, about half million students, who comprised
3 different age group, corresponding to the averages of 11，14, and 17 years, had been examined. A
systematic clinical evaluation was designed for students with proteinuria identified in the mass
screening through ’87... |
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- Spinal Muscular Atrophy Type 2 in Siblings.
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Jeong Sam Jeon, Dong Hub Lee, Byung Soo Cho, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1989;32(5):718-723. Published online May 31, 1989
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We experienced two cases of spinal muscular atrophy, type 2 in 1 year 11 months old boy and 4 year
1 month old girl with the complaint of progressive muscular weakness on both lower extremities (frog
leg position).
Their development had been almost normal since birth and they could stand alone briefly at 12
months of age, but progressive muscular weakness had been apparent... |
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- A Case of Mycoplasmal Meningitis Associated with Mycoplasma Pneumoniae Pneumonia.
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Sang Young Jeong, Seung Koog Kim, Sung Ho Cha, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1989;32(4):556-560. Published online April 30, 1989
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Mycoplasmas have been recognized as pathogens of respiratory tract in children and adolescence,
but clinically apparent pneumonia develops in only 3 to 10% of infected persons.
Central nervous system complication, such as aseptic meningitis, meningoencephalitis. transverse
myelitis, hemiplegia, cerebellar ataxia and psychosis, associated with Mycoplasma pneumoniae
infection were developed in .0.1 % of all Mycoplasmal infection.
We experienced a case of Mycoplasma pneumoniae pneumonia and... |
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- Clinical Study of Encephalitis and Encephalopathy in Children.
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Dong Hunb Lee, Soo Chun Kim, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1989;32(4):500-510. Published online April 30, 1989
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This study was undertaken to evaluate the electronencephalographic and clinical findings in 132
cases of encephalitis and encephalopathy in the Department of Pediatrics, Kyung Hee University
Hospital for 9 years from Jan. 1979 to Dec. 1987.
The results were summerized as follows;
1) The incidence of ecephalitis was 0.46%{86 cases) and the incidence of encephalopathy was 0.25
% (46 cases) among total in-patient (18,671).
2) Male... |
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- Change of Auditory Brainstem Response(ABR) on Neonatal Asphyxia.
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Jeong Sam Jeon, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1989;32(10):1391-1396. Published online October 31, 1989
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Neonatal asphyxia is insult to the newborn due to lack of oxygen or perfusion to various organs.
It is associated with tissue hypoxia, especially brain. So hypoxic-ischemic brain injury is the most
important complication known as hypoxic-ischemic encephalopathy. The EEG as well as various
evoked potentials (auditory, visual and somatosensory) may assist in evaluating the severity of the
damage. This study was undertaken to... |
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- Clinical Study of Patients with Benign Rolandic Epilepsy(BRE).
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Seung Koog Kim, Sung Ho Cha, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1989;32(1):62-66. Published online January 31, 1989
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BRE, probably the commonest varierity of partial epilepsy in childhood has 6 characteristics; it
occurs in children, without neuropsychiatric antecidents, never related to progressive cerebral lesion,
interictal EEG shows Rolandic spikes, the seizure are varied and there is always recovery in puberty
at the latest.
We reviewed 70 patients with BRE to observe the age and sex distribution, EEG findings, clinical
sign and symptoms, treatment... |
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- Changes in Auditory Brainstem Resposes in Hyperbilirubinemic Neonates Before and after Exchange Transfussion and Phototherapy.
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Chong Woo Bae, Young Ho Ra, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1988;31(5):547-554. Published online May 31, 1988
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More recently, several studies of newborns involving ABR testing have demonstrated abnormalities
following an exposure to moderate or severe hyperbilirubinemia. Jaundice in the early neonatal
period is associated with significant transient aberrations of ABR, which suggested transient brain-
stem encephalopathy. So, many authors mentioned that ABR may be a useful tool for the monitoring
of early biliubin toxicity in infants who were at risk... |
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- Clinico-Epidemiological Study on Leprosy Patients in Children.
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Koo Jeoung Jung, Byoung Soo Cho, Sung Ho Cha, Sa Jun Chung, Chang Il Ahn, Do Seo Koo, Do Il Kim
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Clin Exp Pediatr. 1987;30(7):769-776. Published online July 31, 1987
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Clinico-epidemiological study on 44 patients with leprosy in less than 20-year-old children visited to
Institute for Leprosy Research, Korean Leprosy Control Association during past 9 years from
January, 1978, to August, 1986 was carried out and the following results were obtained.
1) Age at time of visit was shown peak in the age group of 16-20 years (34 cases, 77%), but non in
the age... |
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- Significance of Brain CT in Children with Meningitig.
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Myeong Yeon Lee, Byoung Soo Cho, Sa Jun Chung, Yong Mook Choi, Chang Il Ahn
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Clin Exp Pediatr. 1987;30(6):640-650. Published online June 30, 1987
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This study was undertaken to evaluate the significance of brain CT in children with meningitis.
The findings of brain CT in 71 children with meningitis were evaluated in relation to the clinical outcome.
We divided 71 cases into 5 groups according to clinical outcome on discharge, that is, Group I:
Recovery. Group II: Discharge with improvement. Group III: Discharge with residual sequalae. Group
IV:... |
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- Developmental Changes of Auditory Brainstem Responses in Children.
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Jeong Sik Min, Yeong Ho Ra, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1987;30(12):1387-1400. Published online December 31, 1987
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Auditory Brainstem Response(ABR) has been found to be useful for evaluating objective assessment of hearing thresholds, maturation of the brainstem and neurological disorders in the brainstem.
Therefore it is essential to define normal ranges and accurate changes in the wave form of the ABR
in children. This study was undertaken with the analysis of 243 ABR in children with normal
otological, developmental, neurological... |
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- Case Report
- A Case of Recurrent Bacterial Meningitis Secondary to the Defect of Stapes Footplate.
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Soon Hee Eom, Joo Hong Cha, Byoung Soo Cho, Sa Jun Chung, Chang Il Ahn, Chang Il Cha
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Clin Exp Pediatr. 1986;29(7):779-783. Published online July 31, 1986
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With the dramatic lowering the mortality rate of bacterial meningitis since the introduction of
antibacterial agents, multiple attacks of bacterial meningitis no longer are a curiosity. So multiple
attacks of bacterial meningitis may be the only indication of the existence of an abnormal communication
between the nasopharynx or ear and the meningeal space and such a communication must be found.
We... |
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- A Case of Periodic Paralysis.
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In Hwa Lee, Sung Man Kim, Byoung Soo Cho, Sa Jun Chung, Chang II Ahn, Kyung Hoi Ahn
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Clin Exp Pediatr. 1985;28(5):510-513. Published online May 31, 1985
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Periodic paralysis is a group of diseases of unknown cause characterized by recurrent attacks of weakness or paralysis of the limb muscles, accompanied by loss of deep reflexes and failure of the muscles to respond to electrical stimulation. We have experienced a case of periodic paralysis in a 8-year-old boy who had frequent
attacks of flaccid paralysis of the trunk and... |
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- Original Article
- A Clinicoelectroencephalographic Study of Febrile Convulsion in Childhood.
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Kwang Shim, Ook Jung Kang, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1984;27(7):725-732. Published online July 31, 1984
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This study was attempted to reveal the clinical and electrcencephalcgraphic findings of febrile convulsion in children. The subjects were 236 cases, from 6 mos. of age to 15 years of age, who visited to Kyung Hee University Hospital and were diagnosed as febrile convulsion between Jan. 1978 and Aug. 1983. They were classified into 2 categories; simple febrile convulsion (SFC)... |
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- Role of Lumbar Puncture in Children with First Febrile Convulsion.
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Kyu Chul Choi, Byoung Soo Cho, Sa Jun Chung, Yong Mook Choi, Chang Il Ahn
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Clin Exp Pediatr. 1984;27(7):718-724. Published online July 31, 1984
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To assess the role of lumbar puncture in the children with their first febrile convulsion, the results of lumbar puncture in 154 children for a 3-year period were reviewed. In the frequency of the causes of febrile convulsion, meningitis and encephalitis were the most common (34.4%) and upper respiratory tract infection was the next(26.0%). The comparison and observations between the... |
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- Case Report
- 2 Cases of Congenital Asplenia Syndrome.
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Hyo Sup Joo, Chung Hye Chu, Byoung Soo Cho, Kyoo Hwan Rhee, Sa Jun Chung, Chang Il Ahn
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Clin Exp Pediatr. 1984;27(2):191-196. Published online February 28, 1984
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The asplenia syndrome is rare, characterized by congenital abscence of spleen, cardiovascular anomalies and other malformations or malpositions such as total or partial situs inversus, symmetrical lobulation of the liver and/or lung. Associated multiple complex cardiovascular anomalies include common atrioventricular canal, pulmonary stenosis or atresia, anomalous venous drainage and transposition of great vessels. Two-dimensional echocardiography allows the accurate non invasive... |
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- A Case of Neonatal Group B Streptococcal Meningitis.
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Hyuun Kil Yoon, Phil Joun Song, Kyu Chul Choi, Chung Hye Chu, Byoung Soo Cho, Sa Jun Chung
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Clin Exp Pediatr. 1984;27(10):1011-1017. Published online October 31, 1984
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Since 1970, the group B streptococcus has become significant cause of neonatal septicemia and meningitis. Two clinically and epidemiologically distinct types of illness have been described among neonate and infants, that is early and late onset type. We have recently experienced a case of late onset group B streptococcal infection, presented as meningitis and confirmed by Slidex Strepto-Kit. We believe... |
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